ansible/playbooks/test_replace.yml

- hosts: nas
  name: Sync mailu
  ignore_unreachable: false
  vars:
      app_path: "<MAIL_SERVER>25,143,465,993,995,587>192.168.77.106>dsadsad dsad dasdas-ddasd>TCP><WEB_SERVER>443,80>192.168.77.106>>TCP>"
  tasks:
    - name: Print the gateway for each host when defined
      ansible.builtin.debug:
        msg: var is {{ app_path }}
    - set_fact:
        app_path: "{{ app_path | regex_replace('(\\<MAIL_SERVER\\>[0-9,]{1,}\\>)([0-9.]{1,})(\\>[0-9a-zA-Z\\s-]{0,}\\>TCP\\>)', '\\1dasdasdsad\\3') | regex_replace('(\\<WEB_SERVER\\>[0-9,]{1,}\\>)([0-9.]{1,})(\\>[0-9a-zA-Z\\s-]{0,}\\>TCP\\>)', '\\1ddadada\\3') }}" 
    - debug: var is {{ app_path }}